Van de Ven Double Ends Everton's Unbeaten Streak at New Home Ground
The Dutch defender became the first defender to net two goals in a Premier League match for Spurs since Jan Vertonghen in spring 2013.
Match summary
Micky Van de Ven heads into the net twice in opening period
The home side's Jake O'Brien has goal ruled after VAR review
Pape Matar Sarr nets final goal in 89th minute
This loss is the Merseyside club's initial at their new ground
Micky van de Ven found the net twice as Spurs prolonged their winning streak in away games in the top division and handed Everton their initial loss at Hill Dickinson Stadium.
The Toffees were undefeated in their last five matches at their new ground at the dockside location, having departed their historic home behind after more than a century at the end of last season.
But Spurs captain the Dutchman pounced twice from set-pieces in the opening 45 minutes to put their impressive record at jeopardy, and they were unable to turn it around before Pape Matar Sarr - set up by former Toffees attacker the Brazilian - nodded in a final goal to seal the victory.
The Everton defender believed he had levelled the tally five minutes after the defender's opener, directing a powerful header past the Spurs keeper from an Everton corner.
Beto, in the meantime, failed to convert a handful of opportunities, while the Italian goalkeeper made a succession of fine saves to ensure the London club went five matches on the road unbeaten in the Premier League.
But the VAR intervened, advising the match official to check the goal on the screen and the referee ruled that the winger and Iliman Ndiaye were in offside positions and had interfered with the Tottenham goalkeeper.
This victory elevates the manager's team up to third in the division, five points off north London rivals and leaders the Gunners.
The Merseyside club remain 14th and sit six points ahead of the relegation zone.
Tottenham analysis: The defender fulfils role at both ends of pitch
After a uninspiring midweek display in the Champions League against Monaco, where they managed a mere two shots on goal, the manager opted for the French striker in attack instead of former Toffees player Richarlison.
The summer signing was unable to influence the game before being replaced for the substitute after 60 minutes on the pitch, but it turns out he proved unnecessary in the end.
Centre-back the Dutchman converted into an offensive threat to be reckoned with.
Spurs' opening strike came from a well-worked corner routine, with Rodrigo Bentancur directing the ball toward the six-yard box for an free Van de Ven to score.
And the captain - filling in as skipper in Cristian Romero's unavailability - notched his second in added time as he rose above the England keeper to nod in.
The Dutchman was equally impressive in defence, partnering well with his defensive colleague as the duo dealt superbly with the numerous deliveries sent their way by the opposition.
Toffees breakdown: Everton missing finishing touch
The club's recent stadium had been a happy hunting ground, but it appears the novelty may have faded somewhat and fans flocked to the gates after the midfielder's third for Tottenham.
The end in Everton's unbeaten home run won't be a massive concern for David Moyes, but their attacking woes are.
Beto and Thierno Barry - the Toffees' pair of established strikers - had scored just one league goal between them before the weekend's outing.
And they were failed to add to that miserable record on a damp and dreary evening on in Liverpool.
Beto's form was summed up when he opted to overhead kick a clear chance from near the goal, even with having room and time to readjust for a more conventional shot that would have tested Vicario.
The substitute, as well, was unable to make an impact after coming on for the starter in the 65th minute.
It wasn't for a lack of chance. The majority of the home side's attacks came through Grealish and Ndiaye, who tirelessly delivered dangerous crosses into the Tottenham box.
Upcoming fixtures for both teams?
The Toffees: Moyes' men travel to the Stadium of Light in the Premier League on early November at 8 PM.
Tottenham: The London club travel to St James' Park on Wednesday, 29 October for their next round League Cup match against the Magpies.